通过催化转移氢解同时去除5'-O-(2-脱氧-α-D-吡喃葡萄糖基)尿苷中的苄基和苄氧羰基保护基团。
Simultaneous removal of benzyl and benzyloxycarbonyl protective groups in 5'-O-(2-deoxy-alpha-D-glucopyranosyl)uridine by catalytic transfer hydrogenolysis.
作者信息
Wandzik Ilona, Bieg Tadeusz, Kadela Monika
机构信息
Department of Organic Chemistry, Faculty of Chemistry, Silesian University of Technology, Gliwice, Poland.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2008 Dec;27(12):1250-6. doi: 10.1080/15257770802458303.
PMID:19003570
Abstract
Synthesis of N(3),2',3'-O-tris-(benzyloxycarbonyl)uridine and its use in the synthesis of 5'-O-(2-deoxy-alpha-d-glucopyranosyl)uridine is described. Simultaneous removal of benzyl and benzyloxycarbonyl groups was accomplished by catalytic transfer hydrogenolysis in the presence of Pearlman's catalyst without competing side reactions.
摘要
描述了N(3),2',3'-O-三-(苄氧羰基)尿苷的合成及其在5'-O-(2-脱氧-α-D-吡喃葡萄糖基)尿苷合成中的应用。在Pearlman催化剂存在下通过催化转移氢解同时除去苄基和苄氧羰基，且无竞争性副反应。
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