多孢毛霉对土木香内酯的微生物转化
Microbial transformation of alantolactone by Mucor polymorphosporus.
作者信息
Xin Xiu-Lan, Ma Xiao-Chi, Liu Ke-Xin, Han Jian, Wang Bao-Rong, Guo De-An
机构信息
The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China.
出版信息
J Asian Nat Prod Res. 2008 Sep-Oct;10(9-10):933-7. doi: 10.1080/10286020802240301.
Two new transformed sesquiterpenes of alantolactone by Mucor polymorphosporus were obtained. They were characterized as 3beta-hydroxy-11betaH-eudesm-5-en-8beta,12-olide (2) and 3beta,11alpha-dihydroxy-eudesm-5-en-8beta,12-olide (3), on the basis of spectral methods including 2D NMR. And product 3 was an unusual hydroxylation derivative of alantolactone at C-11.
通过多形毛霉得到了两个新的土木香内酯转化倍半萜。基于包括二维核磁共振在内的光谱方法，它们被鉴定为3β-羟基-11βH-桉叶-5-烯-8β,12-内酯（2）和3β,11α-二羟基-桉叶-5-烯-8β,12-内酯（3）。产物3是土木香内酯在C-11位的一种不寻常的羟基化衍生物。
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