Akinwuntan A L, Adesina O A, Okolo C A, Oluwasola O A, Oladokun A, Ifemeje A A, Adewole I F
Department of Obstetrics and Gynaecology, University College Hospital, Ibadan, Nigeria.
J Obstet Gynaecol. 2008 Aug;28(6):638-41. doi: 10.1080/01443610802259977.
The prevalence of squamous intraepithelial lesion is higher among human immunodeficiency virus (HIV)-positive women. These lesions when they occur in these patients are also more difficult to treat. A total of 205 consenting HIV-seropositive women were recruited. A cervical cytology (Pap smear) was taken, followed by visual inspection with freshly prepared 5% acetic acid and cervical biopsy taken from the squamocolumnar junction as the reference for diagnosis to avoid verification bias. The sensitivity of VIA was 76.0% (95% CI 52.0-91.0); specificity 83.0% (95% CI 77.0-88.0); positive predictive value 34.0% (95% CI 21.0-49.0). The sensitivity of cervical cytology (Pap smear) was 57.0% (95% CI 34.0-77.0), specificity of 95.0% (95% CI 90.0-97.0), and positive predictive value of 55.0% (95% CI 33.0-75.0). In HIV-seropositive women, the sensitivity of VIA is 76.0%, making it a useful screening test for preinvasive lesion of the cervix in low resource settings.
在人类免疫缺陷病毒（HIV）阳性女性中，鳞状上皮内病变的患病率较高。这些病变在这些患者中出现时也更难治疗。共招募了205名同意参与的HIV血清阳性女性。进行了宫颈细胞学检查（巴氏涂片），随后用新配制的5%醋酸进行目视检查，并从鳞柱交界处取宫颈活检组织作为诊断参考，以避免验证偏倚。醋酸目视检查（VIA）的敏感性为76.0%（95%可信区间52.0 - 91.0）；特异性为83.0%（95%可信区间77.0 - 88.0）；阳性预测值为34.0%（95%可信区间21.0 - 49.0）。宫颈细胞学检查（巴氏涂片）的敏感性为57.0%（95%可信区间34.0 - 77.0），特异性为95.0%（95%可信区间90.0 - 97.0），阳性预测值为55.0%（95%可信区间33.0 - 75.0）。在HIV血清阳性女性中，醋酸目视检查的敏感性为76.0%，使其成为资源匮乏地区宫颈浸润前病变的一种有用筛查试验。
