Higuchi Tomoyuki, Shirai Nobuya, Suzuki Hiramitsu, Kawashima Masaru, Tamura Yutaka
High Technology Research Center, Kagawa Nutrition University, 3-9-21, Chiyoda, Sakado, Saitama 350-0288, Japan.
Int J Vitam Nutr Res. 2008 May;78(3):129-38. doi: 10.1024/0300-9831.78.3.129.
The aim of this study is to clarify the effects of yogurt supplemented with fish oil on plasma lipid and glucose concentrations, and hepatic lipid contents in mice. Male Crlj:CD-1 (ICR) mice were fed five experimental diets for 12 weeks. The experimental diets were as follows: without yogurt and fish oil (control diet); 10% (w/w) yogurt without fish oil [10% FO(-)]; 10% yogurt with fish oil [10% FO(+)]; 30% yogurt without fish oil [30% FO(-)]; 30% yogurt with fish oil [30% FO(+)]. Plasma triacylglycerol concentrations in the 10% FO(+) and 30% FO(-) groups were significantly lower than that in the control diet group (p < 0.05 and p < 0.05, respectively). Plasma total cholesterol and phospholipid concentrations were significantly lower in the 30% FO(+) group than in the control diet group (p < 0.005). Concentrations tended to be lower with supplementation with fish oil. Plasma glucose concentrations in the 10% FO(+) and 30% FO(+) groups were significantly lower than those in the control diet group (p < 0.005 and p < 0.01, respectively). Hepatic triacylglycerol and total cholesterol contents in the 30% FO(+) group were significantly lower than those in the control diet group (p < 0.05 and p < 0.005, respectively). These results suggest that plasma triacylglycerol and glucose concentrations are effectively decreased by supplementation of yogurt with fish oil.
本研究的目的是阐明添加鱼油的酸奶对小鼠血浆脂质和葡萄糖浓度以及肝脏脂质含量的影响。雄性Crlj:CD-1（ICR）小鼠喂食五种实验性饮食，为期12周。实验性饮食如下：无酸奶和鱼油（对照饮食）；10%（w/w）无鱼油的酸奶[10% FO(-)]；10%含鱼油的酸奶[10% FO(+)]；30%无鱼油的酸奶[30% FO(-)]；30%含鱼油的酸奶[30% FO(+)]。10% FO(+)组和30% FO(-)组的血浆三酰甘油浓度显著低于对照饮食组（分别为p < 0.05和p < 0.05）。30% FO(+)组的血浆总胆固醇和磷脂浓度显著低于对照饮食组（p < 0.005）。添加鱼油后浓度有降低趋势。10% FO(+)组和30% FO(+)组的血浆葡萄糖浓度显著低于对照饮食组（分别为p < 0.005和p < 0.01）。30% FO(+)组的肝脏三酰甘油和总胆固醇含量显著低于对照饮食组（分别为p < 0.05和p < 0.005）。这些结果表明，添加鱼油的酸奶可有效降低血浆三酰甘油和葡萄糖浓度。
