Belmalih Abdelouahed, Borra Elena, Contini Massimo, Gerbella Marzio, Rozzi Stefano, Luppino Giuseppe
Dipartimento di Neuroscienze, Sezione di Fisiologia, Università di Parma, I-43100 Parma, Italy.
J Comp Neurol. 2009 Jan 10;512(2):183-217. doi: 10.1002/cne.21892.
We used a cyto-, myelo-, and chemoarchitectonic (distribution of SMI-32 and calbindin immunoreactivity) approach to assess whether the rostral histochemical area F5 of the ventral premotor cortex (PMv) comprises architectonically distinct areas, possibly corresponding to functionally different fields. Three areas were identified, occupying different parts of F5. One area, designated as "convexity" F5 (F5c), extends on the postarcuate convexity cortex adjacent to the inferior arcuate sulcus and is characterized, cytoarchitectonically, by a poorly laminated appearance, resulting from an overall cell population rather homogeneous in size and density. The other two areas, designated as "posterior" and "anterior" F5 (F5p and F5a, respectively), lie within the postarcuate bank at different anteroposterior levels. Major cytoarchitectonic features of F5p are a layer III relatively homogeneous in cell size and density, a cell-dense layer Va, and the presence of relatively large pyramids in layer Vb. Major cytoarchitectonic features of F5a are the presence of relatively large pyramids in lowest layer III and a prominent, homogenous layer V. Furthermore, our results showed that F5c and F5p border caudally with a caudal PMv area corresponding to histochemical area F4, providing additional evidence for a general subdivision of the macaque PMv into a caudal and a rostral part, corresponding to F4 and to the F5 complex, respectively. The present data, together with other functional and connectional data, suggest that the three rostral PMv areas F5p, F5a, and F5c correspond to distinct cortical entities, possibly involved in different aspects of motor control and cognitive motor functions.
我们采用细胞构筑学、髓鞘构筑学以及化学构筑学方法（SMI-32和钙结合蛋白免疫反应性分布）来评估腹侧运动前区皮质（PMv）嘴侧组织化学区域F5是否包含结构上不同的区域，这些区域可能对应功能上不同的脑区。我们识别出三个区域，它们占据F5的不同部分。一个区域，被指定为“凸面”F5（F5c），延伸至与下弓形沟相邻的弓形后凸皮质，在细胞构筑学上，其特征是分层不明显，这是由于总体细胞群体在大小和密度上较为均匀所致。另外两个区域，分别被指定为“后部”和“前部”F5（F5p和F5a），位于弓形后岸不同的前后水平位置。F5p的主要细胞构筑学特征是Ⅲ层细胞大小和密度相对均匀、细胞密集的Ⅴa层以及Ⅴb层存在相对较大的锥体神经元。F5a的主要细胞构筑学特征是最下层Ⅲ存在相对较大的锥体神经元以及显著的、均匀的Ⅴ层。此外，我们的结果表明，F5c和F5p在尾侧与对应组织化学区域F4的尾侧PMv区域相邻，这为将猕猴PMv总体分为尾侧和嘴侧部分提供了额外证据，这两部分分别对应F4和F5复合体。目前的数据，连同其他功能和连接数据表明，嘴侧PMv的三个区域F5p、F5a和F5c对应不同的皮质实体，可能参与运动控制和认知运动功能的不同方面。
