一种基于微珠流动的二维凝胶图像斑点检测方法。

A method based on bead flows for spot detection on 2-D gel images.

作者信息

Langella Olivier, Zivy Michel

机构信息

CNRS, UMR 0320/UMR 8120 Génétique Végétale, Gif-sur-Yvette, France.

出版信息

Proteomics. 2008 Dec;8(23-24):4914-8. doi: 10.1002/pmic.200800644.

DOI:10.1002/pmic.200800644

PMID:19003871

Abstract

A method has been developed to detect spots on 2-D gel images. It is based on an analogy with beads flowing uphill on the surface of the gel image and on the analysis of their paths. This method does not need image smoothing, thereby allowing for conservation of the resolution of the original image. In addition, it allows for the detection of overlapping spots, even when there is no valley between their centres.

摘要

已经开发出一种检测二维凝胶图像上斑点的方法。它基于一种类比，即珠子在凝胶图像表面向上流动，并对其路径进行分析。这种方法不需要图像平滑处理，从而能够保留原始图像的分辨率。此外，即使斑点中心之间没有谷值，它也能检测到重叠的斑点。