Gendon Iu Z
Zh Mikrobiol Epidemiol Immunobiol. 2008 Sep-Oct(5):109-18.
Data on influenza pandemics as well as on the characteristics of influenza viruses, which caused pandemicsin 1918, 1957, 1968, and 1977 are presented. Mechanisms of pandemic influenza virus strains evolving, including mutations resulting in increase of virulence, as well as possibility of human and avian influenza viruses reassortment process as the source of pandemic strains are discussed. Mechanisms of transformation of mildly virulent influenza virus strains to highly virulent, which can cause epizootics, are reviewed. Genes and proteins determining species specificity of avian influenza viruses as well as possible emergence of influenza pandemic caused by H5N1 strain are discussed. Suggestion of low probability of such event is expressed.
文中呈现了关于流感大流行的数据以及1918年、1957年、1968年和1977年引发大流行的流感病毒的特征。讨论了大流行性流感病毒株演变的机制，包括导致毒力增加的突变，以及人类和禽流感病毒重配过程作为大流行毒株来源的可能性。综述了轻度毒力流感病毒株转变为高毒力毒株从而引发动物流行病的机制。讨论了决定禽流感病毒种属特异性的基因和蛋白质，以及由H5N1毒株引起流感大流行的可能出现情况。文中表示此类事件发生的可能性较低。
