Fedotova I B, Surina N M, Malikova L A, Raevskiĭ K S, Poletaeva I I
Zh Vyssh Nerv Deiat Im I P Pavlova. 2008 Sep-Oct;58(5):620-7.
The duration and severity of cataleptic freezing after audiogenic seizures were investigated in rats of several genotypes with different predisposition to audiogenic epilepsy. These genotypes were the Krushinsky-Molodkina strain (KM--the audiogenic seizure prone strain), the Wistar and two new substrains selected from hybrids KM x Wistar for high ("4") and low ("0") audiogenic seizure susceptibility. The drug injections, which modulated the audiogenic fit severity, induced the changes in catalepsy too. It was found, that in intact animals cataleptic freezing developed after audiogenic seizures only and was more intense after severe seizures, the correlation coefficient being statistically significant. Levetiracetam (anticonvulsant drug) injections resulted in significant decrease of audiogenic fit severity and cataleptic state in Wistar and KM rats. Caffeine injections resulted in audiogenic seizures accompanied by cataleptic freezing in rats of the substrain "0", selected for audiogenic non-pronness.
在几种对听源性癫痫有不同易感性的基因型大鼠中，研究了听源性惊厥后僵住性冻结的持续时间和严重程度。这些基因型包括克鲁申斯基-莫洛迪纳品系（KM——听源性惊厥易感品系）、Wistar品系以及从KM×Wistar杂交种中选出的两个新亚系，分别具有高（“4”）和低（“0”）听源性惊厥易感性。调节听源性发作严重程度的药物注射也会引起僵住状态的变化。结果发现，在未处理的动物中，僵住性冻结仅在听源性惊厥后出现，且在严重惊厥后更为强烈，相关系数具有统计学意义。左乙拉西坦（抗惊厥药物）注射导致Wistar和KM大鼠的听源性发作严重程度和僵住状态显著降低。咖啡因注射导致在被选作非听源性惊厥易感的“0”亚系大鼠中出现伴有僵住性冻结的听源性惊厥。
