Surina N M, Fedotova I B, Kulikov A V, Poletaeva I I
Zh Vyssh Nerv Deiat Im I P Pavlova. 2010 May-Jun;60(3):364-71.
Proportion of animals which developed pinch-induced catalepsy and the duration of this state were analyzed in rats of several genotypes which differed in audiogenic epilepsy proneness and compared with "audiogenic" catalepsy after a sound-induced seizure fit. The following genotypes were studied: Wistar, KM (Krushinsky-Molodkina) strain and substrains "4" and "0" (selected from KM and Wistar hybrid population for high "4" and low "0" audiogenic epilepsy proneness). Adult KM and substrain "4" rats developed the most intense pinch induced catalepsy, whereas Wistar and 2-month-old KM showed practically no catalepsy. After a single sound exposure pinch-induced catalepsy developed in all animals which demonstrated an audiogenic seizure fit--in KM, substrain "4", part of Wistar rats and several animals of substrain "0", latency of the fit onset in all rats being shorter than initially. After sound exposure pinch-induced catalepsy was revealed even in those substrain "0" rats, which demonstrated no audiogenic fits. It is suggested that despite the phenomenological similarity between cataleptic states of different origin (pinch-induced, "audiogenic") their neurophysiologic substrates overlap only partially. The findings are considered as presenting genetic model for further analysis of catalepsy.
对几种在听源性癫痫易感性方面存在差异的基因型大鼠中出现夹捏诱导性僵住症的动物比例及其持续时间进行了分析，并与声音诱发癫痫发作后出现的“听源性”僵住症进行了比较。研究了以下基因型：Wistar、KM（克鲁申斯基 - 莫洛金娜）品系以及品系“4”和“0”的亚系（从KM和Wistar杂交群体中选出，品系“4”具有高听源性癫痫易感性，品系“0”具有低听源性癫痫易感性）。成年KM和品系“4”的大鼠出现了最强烈的夹捏诱导性僵住症，而Wistar大鼠和2月龄的KM大鼠几乎没有出现僵住症。在单次声音暴露后，所有出现听源性癫痫发作的动物——KM、品系“4”、部分Wistar大鼠以及品系“0”的几只动物，都出现了夹捏诱导性僵住症，所有大鼠发作开始的潜伏期都比最初短。即使在那些没有出现听源性发作的品系“0”大鼠中，声音暴露后也发现了夹捏诱导性僵住症。研究表明，尽管不同起源的僵住症状态（夹捏诱导性、“听源性”）在现象学上具有相似性，但它们的神经生理底物仅部分重叠。这些发现被认为是用于进一步分析僵住症的遗传模型。
