尿苷对克鲁申斯基-莫洛迪纳品系大鼠听源性强直性惊厥发育影响的研究。

Study of Uridine Effect on the Development of Audiogenic Tonic Seizures in Krushinsky-Molodkina Strain Rats.

作者信息

Fedotova I B, Nikolaev G M, Perepelkina O V, Belosludtseva N V, Mironova G D, Poletaeva I I

机构信息

Biology Department, Moscow State University, Moscow, 119234, Russia.

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Poushchino, Moscow oblast, 142290, Russia.

出版信息

Dokl Biol Sci. 2018 Jul;481(1):125-127. doi: 10.1134/S0012496618040014. Epub 2018 Aug 31.

DOI:10.1134/S0012496618040014

PMID:30171462

Abstract

The latency of tonic seizure in response to loud sound (in rats of the Krushinsky-Molodkina strain with audiogenic epilepsy) had been slightly (although statistically significantly) longer after chronic uridine injections (100 mg/kg, i.p., three times a day during 9 or 12 days). The recovery time from the tonic seizure was shorter after 12 days of injections in comparison to the 9-day injection period. At the same time, the intensity of tonic seizures provoked by loud sound did not change after chronic uridine injections. The lack of uridine anticonvulsive effect demonstrated in the audiogenic epilepsy model contradicts the anticonvulsant effects of uridine in experiments with other seizure models, in which the epileptic foci were localized in the forebrain structures.

摘要

在对大声刺激产生的强直性惊厥潜伏期方面（在患有听源性癫痫的克鲁申斯基-莫洛迪纳品系大鼠中），慢性注射尿苷（100毫克/千克，腹腔注射，每天三次，持续9天或12天）后，潜伏期略有延长（尽管在统计学上有显著差异）。与9天的注射期相比，注射12天后强直性惊厥的恢复时间更短。同时，慢性注射尿苷后，大声刺激引发的强直性惊厥强度并未改变。在听源性癫痫模型中所显示的尿苷缺乏抗惊厥作用，与尿苷在其他癫痫模型实验中的抗惊厥作用相矛盾，在其他模型中癫痫病灶位于前脑结构。