Department of Epidemiology, Erasmus University Medical Center Rotterdam, The Netherlands.
Neurobiol Aging. 2010 Oct;31(10):1831-3. doi: 10.1016/j.neurobiolaging.2008.09.015. Epub 2008 Nov 11.
The E4 allele of the apolipoprotein E gene (APOE) is a well-established determinant of Alzheimer's disease but its relation to cognitive function is much less understood. We studied the age-specific effects of the APOEE4 allele on cognitive function and cardiovascular risk factors in 2208 related individuals. APOEE4 allele was significantly associated with reduced test scores for Adult Verbal Learning Test, particularly on the memory and learning sub domains, in persons older than 50 years of age. The effect of APOEE4 was independent of the effect of APOEE4 on vascular risk factors and most pronounced on learning ability. Our findings suggest that APOE*E4 has an effect on cognitive function predominantly in the elderly, independent of vascular risk factors.
载脂蛋白 E 基因（APOE）的 E4 等位基因是阿尔茨海默病的一个既定决定因素，但它与认知功能的关系却知之甚少。我们研究了 APOEE4 等位基因对 2208 名相关个体认知功能和心血管危险因素的年龄特异性影响。APOEE4 等位基因与成人言语学习测试的测试分数降低显著相关，尤其是在 50 岁以上人群的记忆和学习子领域。APOEE4 的作用独立于 APOEE4 对血管危险因素的作用，并且在学习能力方面最为明显。我们的研究结果表明，APOE*E4 对认知功能的影响主要发生在老年人中，与血管危险因素无关。
