Commentary: Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk.
作者信息
Dzianok Patrycja, Kublik Ewa
机构信息
Laboratory of Emotions Neurobiology, Nencki Institute of Experimental Biology PAS, Warsaw, Poland.
出版信息
Front Aging Neurosci. 2020 May 8;12:127. doi: 10.3389/fnagi.2020.00127. eCollection 2020.
Abstract
摘要
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Commentary: Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk.评论：载脂蛋白E2、载脂蛋白E3和载脂蛋白E4在人类神经元中介导的差异信号与阿尔茨海默病风险平行。
Front Aging Neurosci. 2020 May 8;12:127. doi: 10.3389/fnagi.2020.00127. eCollection 2020.
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Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk.载脂蛋白 E2、E3 和 E4 通过不同信号通路在人神经元中介导阿尔茨海默病风险。
J Neurosci. 2019 Sep 11;39(37):7408-7427. doi: 10.1523/JNEUROSCI.2994-18.2019. Epub 2019 Jul 22.
2
Glial Control of Synapse Number in Healthy and Diseased Brain.健康和患病大脑中神经胶质细胞对突触数量的调控
Front Cell Neurosci. 2019 Feb 13;13:42. doi: 10.3389/fncel.2019.00042. eCollection 2019.
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The Role of APOE4 in Disrupting the Homeostatic Functions of Astrocytes and Microglia in Aging and Alzheimer's Disease.APOE4在破坏衰老和阿尔茨海默病中星形胶质细胞和小胶质细胞的稳态功能方面的作用。
Front Aging Neurosci. 2019 Feb 11;11:14. doi: 10.3389/fnagi.2019.00014. eCollection 2019.
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Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging.使用突触囊泡糖蛋白 2A 正电子发射断层显像评估阿尔茨海默病中的突触密度。
JAMA Neurol. 2018 Oct 1;75(10):1215-1224. doi: 10.1001/jamaneurol.2018.1836.
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APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types.载脂蛋白 E4 导致与人类 iPSC 衍生脑细胞类型的阿尔茨海默病表型相关的广泛分子和细胞改变。
Neuron. 2018 Jun 27;98(6):1141-1154.e7. doi: 10.1016/j.neuron.2018.05.008. Epub 2018 May 31.
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ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion.载脂蛋白E2、载脂蛋白E3和载脂蛋白E4对淀粉样前体蛋白转录和β淀粉样蛋白分泌的刺激作用存在差异。
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