法国和意大利男性队列中更新后的Partin表的外部验证

External validation of the updated partin tables in a cohort of French and Italian men.

作者信息

Bhojani Naeem, Salomon Laurent, Capitanio Umberto, Suardi Nazareno, Shariat Shahrokh F, Jeldres Claudio, Zini Laurent, Pharand Daniel, Péloquin François, Arjane Philippe, Abbou Claude C, De La Taille Alexandre, Montorsi Francesco, Karakiewicz Pierre I

机构信息

Cancer Prognostics and Health Outcomes Unit, University of Montreal, Montreal, PQ, Canada.

出版信息

Int J Radiat Oncol Biol Phys. 2009 Feb 1;73(2):347-52. doi: 10.1016/j.ijrobp.2008.04.082. Epub 2008 Nov 10.

DOI:10.1016/j.ijrobp.2008.04.082

PMID:19004573

Abstract

PURPOSE

To test the discrimination and calibration properties of the newly developed 2007 Partin Tables in two European cohorts with localized prostate cancer.

METHODS

Data on clinical and pathologic characteristics were obtained for 1,064 men treated with radical prostatectomy at the Creteil University Health Center in France (n = 839) and at the Milan University Vita-Salute in Italy (n = 225). Overall discrimination was assessed with receiver operating characteristic curve analysis, which quantified the accuracy of stage predictions for each center. Calibration plots graphically explored the relationship between predicted and observed rates of extracapsular extension (ECE), seminal vesicle invasion (SVI) and lymph node invasion (LNI).

RESULTS

The rates of ECE, SVI, and LNI were 28%, 14%, and 2% in the Creteil cohort vs. 11%, 5%, and 5% in the Milan cohort. In the Creteil cohort, the accuracy of ECE, SVI, and LNI prediction was 61%, 71%, and 82% vs. 66%, 92% and 75% for the Milan cohort. Important departures were recorded between Partin Tables' predicted and observed rates of ECE, SVI, and LNI within both cohorts.

CONCLUSIONS

The 2007 Partin Tables demonstrated worse performance in European men than they originally did in North American men. This indicates that predictive models need to be externally validated before their implementation into clinical practice.

摘要

目的

在两个患有局限性前列腺癌的欧洲队列中测试新开发的2007年Partin表的辨别和校准特性。

方法

获取了法国克雷泰伊大学健康中心（n = 839）和意大利米兰大学圣心大学（n = 225）接受根治性前列腺切除术的1064名男性的临床和病理特征数据。通过受试者工作特征曲线分析评估总体辨别能力，该分析量化了每个中心分期预测的准确性。校准图以图形方式探究了预测的和观察到的包膜外扩展（ECE）、精囊侵犯（SVI）和淋巴结侵犯（LNI）发生率之间的关系。

结果

克雷泰伊队列中ECE、SVI和LNI的发生率分别为28%、14%和2%，而米兰队列中分别为11%、5%和5%。在克雷泰伊队列中，ECE、SVI和LNI预测的准确性分别为61%、71%和82%，而米兰队列为66%、92%和75%。两个队列中Partin表预测的和观察到的ECE、SVI和LNI发生率之间均有显著差异。