与良性前列腺增生相比，Nedd4L在前列腺癌中的表达下调。
Nedd4L expression is downregulated in prostate cancer compared to benign prostatic hyperplasia.
作者信息
Hu X Y, Xu Y M, Fu Q, Yu J J, Huang J
机构信息
Department of Urology, Shanghai Jiaotong University Affiliated 6th People's Hospital, Shanghai Jiaotong University, Shanghai, PR China.
出版信息
Eur J Surg Oncol. 2009 May;35(5):527-31. doi: 10.1016/j.ejso.2008.09.015. Epub 2008 Nov 11.
AIMS
To characterize aspects of Nedd4L in prostate cancer (PC) by assessing its expression in hyperplastic and malignant prostate tissue, and to correlate findings with PC histologic grade.
MATERIALS AND METHODS
Radical prostatectomy (RP) specimens from 56 patients with clinically localized PC, and benign prostatic hyperplasia (BPH) transurethral resection specimens from 31 patients, were assessed for Nedd4L expression using immunohistochemistry.
RESULTS
Nedd4L (P<0.001) expressions were significantly decreased in PC compared to benign prostate tissue. Furthermore, downregulation of Nedd4L (P<0.05) expression correlated with increasing Gleason score.
CONCLUSIONS
These data suggest that prostate cancer cells in vivo may need Nedd4L expression to regulate TGF-beta1 signaling, and that Nedd4L expression might be involved in prostate cancer development.
目的
通过评估Nedd4L在前列腺增生组织和恶性前列腺组织中的表达，来描述其在前列腺癌（PC）中的特征，并将结果与前列腺癌组织学分级相关联。
材料与方法
使用免疫组织化学方法评估56例临床局限性前列腺癌患者的根治性前列腺切除术（RP）标本，以及31例良性前列腺增生（BPH）患者的经尿道前列腺切除术标本中Nedd4L的表达。
结果
与良性前列腺组织相比，前列腺癌中Nedd4L的表达显著降低（P<0.001）。此外，Nedd4L表达下调（P<0.05）与Gleason评分增加相关。
结论
这些数据表明，体内前列腺癌细胞可能需要Nedd4L表达来调节TGF-β1信号通路，并且Nedd4L表达可能参与前列腺癌的发生发展。
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