亚急性硬化性全脑炎中的淋巴因子与免疫调节分子

Lymphokines and immunoregulatory molecules in subacute sclerosing panencephalitis.

作者信息

Hofman F M, Hinton D R, Baemayr J, Weil M, Merrill J E

机构信息

Department of Pathology, University of Southern California School of Medicine, Los Angeles 90033.

出版信息

Clin Immunol Immunopathol. 1991 Mar;58(3):331-42. doi: 10.1016/0090-1229(91)90124-s.

DOI:10.1016/0090-1229(91)90124-s

PMID:1900461

Abstract

Frozen brain specimens from six patients with subacute sclerosing panencephalitis (SSPE) were analyzed immunohistochemically for the presence of leukocyte subpopulations and specific cytokines. In brain regions demonstrating perivascular cell infiltration and gliosis, CD4 and CD8 positive cells were identified within the brain parenchyma. Cytokine analysis revealed cells staining positively for tumor necrosis factor-alpha and interferon-gamma. These results were similar to those observed in multiple sclerosis (MS) and progressive rubella panencephalitis tissue and were different from other predominantly noninflammatory neurologic diseases and normal controls. Although SSPE and MS differ significantly in their etiology and histopathology, the similarities in leukocyte and cytokine staining patterns suggest a common mechanism of disease progression.

摘要

对6例亚急性硬化性全脑炎（SSPE）患者的冷冻脑标本进行免疫组织化学分析，以检测白细胞亚群和特定细胞因子的存在情况。在显示血管周围细胞浸润和胶质增生的脑区，脑实质内可识别出CD4和CD8阳性细胞。细胞因子分析显示，肿瘤坏死因子-α和干扰素-γ染色呈阳性的细胞。这些结果与在多发性硬化症（MS）和进行性风疹全脑炎组织中观察到的结果相似，与其他主要为非炎症性神经系统疾病及正常对照不同。尽管SSPE和MS在病因和组织病理学上有显著差异，但白细胞和细胞因子染色模式的相似性提示了疾病进展的共同机制。