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继发性动脉肠瘘——一项系统的文献分析

Secondary arterioenteric fistulation--a systematic literature analysis.

作者信息

Bergqvist D, Björck M

机构信息

Department of Surgical Sciences, Section of Vascular Surgery, Uppsala University Hospital, Uppsala, Sweden.

出版信息

Eur J Vasc Endovasc Surg. 2009 Jan;37(1):31-42. doi: 10.1016/j.ejvs.2008.09.023. Epub 2008 Nov 12.

Abstract

OBJECTIVE

To analyze the problem of secondary arterioenteric fistulation, a rare but serious complication.

METHODS

A systematic literature review was performed searching for case reports as well as patients included in articles analyzing especially infectious complications.

RESULTS

332 individual cases and 1135 patients from papers on complications were identified. All types of surgery involving aorta and its branches could precede the complication, endovascular procedures included. The development of a fistula can occur at any time after primary surgery, the longest delay being 26 years. Bleeding was the dominating symptom with herald bleeding in more than half of the patients, infectious problems present in around one quarter. Diagnostic delay was typical, although decreasing over time. The mortality was high, lowest after axillobifemoral revascularization and aortic graft removal. The information in the articles is often heterogeneous and incomplete, and follow-up time is often too short. Mortality after fistulation seems to have decreased over time.

CONCLUSION

Secondary arterioenteric fistula continues to be an extremely serious complication after surgery on aorta and its branches. Every effort must be made to arrive at a rapid diagnosis. The best therapeutic option seems to be axillobifemoral revascularization and subsequent graft removal, which however, requires haemodynamically stable patients. Endovascular repair may serve as a bridge to open surgery.

摘要

目的

分析继发性主动脉肠瘘这一罕见但严重的并发症问题。

方法

进行系统的文献综述,检索病例报告以及分析尤其是感染性并发症的文章中纳入的患者。

结果

从关于并发症的论文中识别出332例个体病例和1135例患者。涉及主动脉及其分支的所有类型手术都可能引发该并发症,包括血管内手术。瘘管可在初次手术后的任何时间发生,最长延迟时间为26年。出血是主要症状,超过半数患者有前驱性出血,约四分之一患者存在感染问题。诊断延迟很常见,不过随着时间推移有所减少。死亡率很高,腋股动脉血管重建和主动脉移植物移除术后死亡率最低。文章中的信息往往异质性强且不完整,随访时间通常过短。瘘管形成后的死亡率似乎随时间有所下降。

结论

继发性主动脉肠瘘仍然是主动脉及其分支手术后极其严重的并发症。必须尽一切努力实现快速诊断。最佳治疗选择似乎是腋股动脉血管重建及随后的移植物移除,但这需要患者血流动力学稳定。血管内修复可作为开放手术的桥梁。

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