Luporsi Elisabeth
Centre Alexis-Vautrin, Vandoeuvre-les-Nancy.
Bull Cancer. 2008 Oct;95(10):979-83. doi: 10.1684/bdc.2008.0732.
This review will summarize specific methodological aspects in targeted therapies like EPR (early progression rate) or RDD (randomized discontinuation design), along with Adaptive Design such as CRM (continual reassessment method, Eff-TOX (dose-finding based on efficacy-toxicity, PPD (predictive probability design) or ADTT (adaptive randomization for targeted therapy) methods.
本综述将总结靶向治疗中的特定方法学方面，如早期进展率（EPR）或随机停药设计（RDD），以及适应性设计，如连续重新评估法（CRM）、基于疗效-毒性的剂量寻找法（Eff-TOX）、预测概率设计（PPD）或靶向治疗的适应性随机化（ADTT）方法。
