Arjamaa Olli, Nikinmaa Mikko
Centre of Excellence in Evolutionary Genetics and Physiology, Department of Biology, University of Turku, FI-20014 Turku, Finland.
Am J Physiol Regul Integr Comp Physiol. 2009 Feb;296(2):R257-64. doi: 10.1152/ajpregu.90696.2008. Epub 2008 Nov 12.
The possibility that natriuretic peptides' effects are important in hypoxia responses of vertebrates is reviewed. Both the transcription and release of natriuretic peptides are affected by oxygen tension. Furthermore, many of the effects observed in hypoxia, such as diuresis and a reduction of plasma volume, are also caused by treatment of the animal with natriuretic peptides. Also, several clinical observations about changes in natriuretic peptide levels in, e.g., sleep apnea and cyanotic congenital heart disease, are consistent with the idea that hypoxia is involved in the etiology of conditions, in which natriuretic peptide levels increase. Virtually all published information on the relationship between oxygen and natriuretic peptides is based on human studies. Because hypoxic conditions are more common in aquatic than terrestrial environments, future studies about the possible role of natriuretic peptides in hypoxia, as well as the role of hypoxia in the evolution of natriuretic peptides, including the different subtypes, should increasingly involve also aquatic organisms.
本文综述了利钠肽的作用在脊椎动物缺氧反应中可能具有重要意义这一观点。利钠肽的转录和释放均受氧张力影响。此外，在缺氧时观察到的许多效应，如利尿和血浆量减少，也可由给动物注射利钠肽引起。另外，一些关于例如睡眠呼吸暂停和紫绀型先天性心脏病中利钠肽水平变化的临床观察结果，与缺氧参与利钠肽水平升高的病症病因这一观点一致。几乎所有已发表的关于氧与利钠肽之间关系的信息均基于人体研究。由于缺氧情况在水生环境中比在陆地环境中更为常见，未来关于利钠肽在缺氧中可能作用的研究，以及缺氧在利钠肽（包括不同亚型）进化中的作用研究，应越来越多地纳入水生生物。
