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常见和特定的HLA - DRB1/DQB1单倍型对三个不同阿拉伯人群1型糖尿病遗传易感性的影响。

Influence of common and specific HLA-DRB1/DQB1 haplotypes on genetic susceptibilities of three distinct Arab populations to type 1 diabetes.

作者信息

Stayoussef Mouna, Benmansour Jihen, Al-Jenaidi Fayza A, Nemr Rita, Ali Muhallab E, Mahjoub Touhami, Almawi Wassim Y

机构信息

Faculty of Pharmacy, University of Monastir, Monastir, Tunisia.

出版信息

Clin Vaccine Immunol. 2009 Jan;16(1):136-8. doi: 10.1128/CVI.00215-08. Epub 2008 Nov 12.

DOI:10.1128/CVI.00215-08
PMID:19005023
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2620672/
Abstract

The contribution of HLA DRB-DQB to type 1 diabetes (T1D) in Bahrainis, Lebanese, and Tunisians was investigated. DRB1030101-DQB10201 was a locus that conferred susceptibility in three populations, while DRB1040101-DQB10302 was a locus that conferred susceptibility only in Tunisians and Bahrainis. The DRB1100101-DQB1050101 (Bahrainis) and DRB1150101-DQB1060101 (Lebanese) loci were largely protective. The contribution of HLA to T1D must be evaluated with regard to ethnic background.

摘要

研究了HLA DRB - DQB对巴林人、黎巴嫩人和突尼斯人1型糖尿病（T1D）的影响。DRB1030101 - DQB10201是在三个人群中赋予易感性的一个基因座，而DRB1040101 - DQB10302是仅在突尼斯人和巴林人中赋予易感性的一个基因座。DRB1100101 - DQB1050101（巴林人）和DRB1150101 - DQB1060101（黎巴嫩人）基因座在很大程度上具有保护作用。必须根据种族背景评估HLA对T1D的影响。

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Genetic screening for individuals at high risk for type 1 diabetes in the general population using HLA Class II alleles as disease markers. A comparison between three European populations with variable rates of disease incidence.使用HLA II类等位基因作为疾病标志物，对普通人群中1型糖尿病高危个体进行基因筛查。对三个疾病发病率不同的欧洲人群进行比较。
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HLA alleles and type 1 diabetes mellitus in low disease incidence populations of Southern Europe: a comparison of Greeks and Albanians.南欧低发病率人群中的HLA等位基因与1型糖尿病：希腊人和阿尔巴尼亚人的比较
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