树突棘发育中的微管。
Microtubules in dendritic spine development.
作者信息
Gu Jiaping, Firestein Bonnie L, Zheng James Q
机构信息
Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA.
出版信息
J Neurosci. 2008 Nov 12;28(46):12120-4. doi: 10.1523/JNEUROSCI.2509-08.2008.
Abstract
It is generally believed that only the actin cytoskeleton resides in dendritic spines and controls spine morphology and plasticity. Here, we report that microtubules (MTs) are present in spines and that shRNA knockdown of the MT plus-end-binding protein EB3 significantly reduces spine formation. Furthermore, stabilization and inhibition of MTs by low doses of taxol and nocodazole enhance and impair spine formation elicited by BDNF (brain-derived neurotrophic factor), respectively. Therefore, MTs play an important role in the control and regulation of dendritic spine development and plasticity.
摘要
一般认为，只有肌动蛋白细胞骨架存在于树突棘中，并控制棘的形态和可塑性。在此，我们报告微管（MTs）存在于棘中，并且MT正端结合蛋白EB3的短发夹RNA敲低显著减少了棘的形成。此外，低剂量紫杉醇和诺考达唑对MTs的稳定和抑制分别增强和损害了脑源性神经营养因子（BDNF）引发的棘形成。因此，MTs在树突棘发育和可塑性的控制与调节中起重要作用。
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