Aller R, de Luis D A, Izaola O, Sagrado M Gonzalez, Conde R, Velasco M C, Alvarez T, Pacheco D, González J M
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, C/Los perales 16, 47130, Simancas, Valladolid, Spain.
Dig Dis Sci. 2009 Aug;54(8):1772-7. doi: 10.1007/s10620-008-0539-9. Epub 2008 Nov 14.
Non-alcoholic fatty liver disease (NAFLD) is a common liver disease. The aim of the present study was to explore the relation of visfatin with underlying histopathological changes of NAFLD patients.
A population of 55 NAFLD patients was analyzed in a cross-sectional study. A liver biopsy was realized. Weight, basal glucose, insulin, insulin resistance (HOMA), total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, and visfatin levels were measured. A bioimpedance was performed.
The mean age was 42.8 +/- 11.2 years, the mean BMI was 33.1 +/- 10.2 with 37 males (67.3%) and 18 females (32.7%). Probabilities to have; portal inflammation increased 1.11 (CI95%:1.03-1.50) with each increment of 1 ng/ml of visfatin concentration, high grade of steatosis increased 1.25 (CI 95%:1.06-1.61) with each unit of insulin concentrations, fibrosis increased 1.12 (CI 95%:1.02-1.43) with each unit of fat mass and lobulillar inflammation increased 13.4 (CI 95%:1.3-147) with each unit of HOMA-IR. Portal inflammation frequencies were different between groups (low visfatin group 13.07 < ng/ml: 37.5% versus high visfatin group 13.07 > ng/ml: 62.5%; P < 0.05). In conclusion, several histopathological changes in liver biopsies could be explained by insulin concentrations, HOMA-IR, and fat mass amount. Moreover, visfatin plasma concentrations could predict the presence of portal inflammation in NAFLD patients.
非酒精性脂肪性肝病（NAFLD）是一种常见的肝脏疾病。本研究的目的是探讨内脂素与NAFLD患者潜在组织病理学变化之间的关系。
在一项横断面研究中分析了55例NAFLD患者。进行了肝活检。测量了体重、基础血糖、胰岛素、胰岛素抵抗（HOMA）、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、甘油三酯和内脂素水平。进行了生物电阻抗分析。
平均年龄为42.8±11.2岁，平均BMI为33.1±10.2，其中男性37例（67.3%），女性18例（32.7%）。内脂素浓度每增加1 ng/ml，门静脉炎症的发生概率增加1.11（95%置信区间：1.03 - 1.50）；胰岛素浓度每增加一个单位，重度脂肪变性的发生概率增加1.25（95%置信区间：1.06 - 1.61）；脂肪量每增加一个单位，纤维化的发生概率增加1.12（95%置信区间：1.02 - 1.43）；HOMA-IR每增加一个单位，小叶炎症的发生概率增加13.4（95%置信区间：1.3 - 147）。不同组之间门静脉炎症频率不同（内脂素水平低组<13.07 ng/ml：37.5%，内脂素水平高组>13.07 ng/ml：62.5%；P<0.05）。总之，肝活检中的几种组织病理学变化可以用胰岛素浓度、HOMA-IR和脂肪量来解释。此外，血浆内脂素浓度可以预测NAFLD患者门静脉炎症的存在。
