Center of Investigation of Endocrinology and Clinical Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Spain.
Ann Hepatol. 2011 Jan-Mar;10(1):50-5.
Osteocalcin is a hormone with a complex cross-talk between adipose tissue and the skeleton. The aim of the present study was to explore the relation of osteocalcin with histopathological changes of NALFD patients.
A population of 69 NAFLD patients was analyzed. A liver biopsy was realized. Weight, fat mass, body mass index, basal glucose, insulin, insulin resistance (HOMA), total cholesterol, LDLcholesterol, HDL-cholesterol, triglycerides and osteocalcin levels were measured.
Patients were divided in two groups by median osteocalcin value (11.34 ng/mL), group I (patients with the low values) and group II (patients with the high values). Only liver fibrosis frequencies were different between groups (group I: 22.9% vs group II: 9.4%; p < 0.05). Patients in group I had higher levels of glucose (115.6 ± 28.1 mg/dL vs. 103.7 ± 24.3 mg/dL; p < 0.04), HOMA (4.6 ± 3.1 units vs. 3.6 ± 1.8 units; p < 0.04), weight (102.9 ± 32.4 kg vs. 85.9 ± 16.8 kg; p = 0.002) and body mass index (38.3 ± 11.4 kg/m(2) vs. 30.1 ± 5.7 kg/m(2); p = 0.001)) than patients in group II. Osteocalcin was inverse correlated with glucose (r =-0.4; p = 0.002) and HOMA (r = -0.3:p = 0.01).
Osteocalcin is associated with liver fibrosis. However, this association disappeared in a multivariate analysis, and HOMA remained as an independent factor.
骨钙素是一种具有脂肪组织和骨骼之间复杂串扰的激素。本研究旨在探讨骨钙素与 NALFD 患者组织病理学变化的关系。
分析了 69 名非酒精性脂肪性肝病患者。进行了肝活检。测量体重、脂肪量、体重指数、基础血糖、胰岛素、胰岛素抵抗（HOMA）、总胆固醇、LDL 胆固醇、HDL 胆固醇、甘油三酯和骨钙素水平。
根据骨钙素中位数（11.34ng/ml）将患者分为两组，I 组（低值组）和 II 组（高值组）。仅肝纤维化频率在两组之间存在差异（I 组：22.9% vs. II 组：9.4%；p<0.05）。I 组患者的血糖（115.6±28.1mg/dL 与 103.7±24.3mg/dL；p<0.04）、HOMA（4.6±3.1 单位与 3.6±1.8 单位；p<0.04）、体重（102.9±32.4kg 与 85.9±16.8kg；p=0.002）和体重指数（38.3±11.4kg/m2 与 30.1±5.7kg/m2；p=0.001）均高于 II 组。骨钙素与血糖呈负相关（r=-0.4；p=0.002）和 HOMA（r=-0.3；p=0.01）。
骨钙素与肝纤维化相关。然而，这种相关性在多变量分析中消失，HOMA 仍然是一个独立的因素。
