Baguley Ian J, Nott Melissa T, Slewa-Younan Shameran
Brain Injury Rehabilitation Service, Westmead Hospital, Sydney, Australia.
Brain Inj. 2008 Nov;22(12):919-25. doi: 10.1080/02699050802448578.
To investigate mortality trends in functionally dependent adults following traumatic brain injury (TBI).
Data for 966 consecutive admissions to a specialist TBI rehabilitation service were reviewed. Details for 69 subjects who were functionally dependent at rehabilitation discharge were cross-referenced against the State Government Death Register. The observed mortality rate was compared to an equivalent population sample derived from Australian Life Tables.
Twenty-five subjects (36%) were deceased at an average 10.5 years post-injury (SD 5 years; range 1.7-18.8 years). The observed numbers of deaths far exceeded the expected population figure (1.9) for the same period (1989-2007) yielding a standardized mortality rate of 13.2. Mortality trends suggested a bimodal distribution, with more deaths in the first 5 years post-injury followed by no further deaths until 9 years post-injury.
Mortality in this functionally-dependent group was significantly associated with age, male sex and degree of disability at discharge. The bimodal distribution of mortality data suggests different contributory mechanisms to early vs. late mortality in this group.
调查创伤性脑损伤（TBI）后功能依赖成年人的死亡率趋势。
回顾了连续966例入住专科TBI康复服务机构的患者数据。将69例康复出院时功能依赖的患者详细信息与州政府死亡登记册进行交叉比对。将观察到的死亡率与来自澳大利亚生命表的同等人群样本进行比较。
25例患者（36%）在受伤后平均10.5年（标准差5年；范围1.7 - 18.8年）死亡。观察到的死亡人数远远超过同期（1989 - 2007年）预期的人群数字（1.9），标准化死亡率为13.2。死亡率趋势呈双峰分布，受伤后前5年死亡人数较多，之后直至受伤后9年无进一步死亡。
该功能依赖组的死亡率与年龄、男性性别和出院时残疾程度显著相关。死亡率数据的双峰分布表明该组早期和晚期死亡的促成机制不同。
