Poltawski Leon, Edwards Hazel, Todd Amy, Watson Tim, Lees Andrew, James Cherry Ann
Division of Physiotherapy, University of Hertfordshire, UK.
Mov Disord. 2009 Jan 15;24(1):115-8. doi: 10.1002/mds.22316.
Apomorphine hydrochloride is a dopamine agonist used in the treatment of advanced Parkinson's disease. Its administration by subcutaneous infusions is associated with the development of nodules that may interfere with absorption of the drug. This pilot study assessed the effectiveness of ultrasound (US) in the treatment of these nodules. Twelve participants were randomly assigned to receive a course of real or sham US on an area judged unsuitable for infusion. Following treatment, no significant change was observed in measures of tissue hardness and tenderness. However, 5 of 6 participants receiving real US rated the treated area suitable for infusion compared with the 1 of 6 receiving sham US. Sonographic appearance improved in both groups, but more substantially in the real US group. Power calculations suggest a total sample size of 30 would be required to establish statistical significance. A full-scale study of the effectiveness of therapeutic US in the treatment of apomorphine nodules is warranted.
盐酸阿扑吗啡是一种用于治疗晚期帕金森病的多巴胺激动剂。通过皮下输注给药时，会出现结节，可能会影响药物吸收。这项初步研究评估了超声（US）治疗这些结节的有效性。12名参与者被随机分配到一个被判定不适合输注的区域接受真正的或假的超声治疗疗程。治疗后，组织硬度和压痛测量值未见显著变化。然而，接受真正超声治疗的6名参与者中有5名认为治疗区域适合输注，而接受假超声治疗的6名参与者中只有1名这样认为。两组的超声表现均有改善，但真正超声治疗组改善更明显。功效计算表明，需要30名的总样本量才能确定统计学意义。有必要对治疗性超声治疗阿扑吗啡结节的有效性进行全面研究。
