Hancu Ileana
GE Global Research Center, Niskayuna, New York 12309, USA.
NMR Biomed. 2009 May;22(4):426-35. doi: 10.1002/nbm.1353.
Optimized myo-inositol (mI) detection is important for diagnosing and monitoring a multitude of pathological conditions of the brain. Simulations are presented in this work, performed to decide which pulse sequence has the most significant advantage in terms of improving repeatability and accuracy of mI measurements at 3T over the pulse sequence used typically in the clinic, a TE = 35 ms PRESS sequence. Five classes of pulse sequences, four previously suggested for optimized mI detection (a short TE PRESS, a Carr-Purcell PRESS sequence, an optimized STEAM sequence, an optimized zero quantum filter), and one optimized for mI detection in this work (a single quantum filter) were compared to a standard, TE = 35 ms pulse sequence. While limiting the SNR of an acquisition to the equivalent SNR of a spectrum acquired in 5 min from an 8 cc voxel, it was found through simulations that the most repeatable mI measurements would be obtained with a Carr-Purcell sequence. This sequence was implemented in a clinical scanner, and improved mI measurements were demonstrated in vivo.
优化肌醇（mI）检测对于诊断和监测多种脑部病理状况至关重要。本文展示了相关模拟，旨在确定在3T条件下，相较于临床常用的TE = 35 ms的PRESS序列，哪种脉冲序列在提高mI测量的重复性和准确性方面具有最显著优势。比较了五类脉冲序列，其中四类是先前为优化mI检测而提出的（短TE的PRESS序列、Carr-Purcell PRESS序列、优化的STEAM序列、优化的零量子滤波器），还有一类是本文为mI检测优化的（单量子滤波器），并与标准的TE = 35 ms脉冲序列进行比较。在将采集的信噪比限制为从8 cc体素在5分钟内采集的频谱的等效信噪比的情况下，通过模拟发现，使用Carr-Purcell序列可获得最可重复的mI测量结果。该序列已在临床扫描仪中实现，并在体内证明了其改善的mI测量效果。
