Ridder William H
Southern California College of Optometry, 2575 Yorba Linda Boulevard, Fullerton, CA 92831, USA.
Expert Opin Pharmacother. 2008 Dec;9(17):3121-8. doi: 10.1517/14656560802500613.
Dry eye disease is one of the most commonly encountered conditions in eye care, and inflammation is a frequent finding. Ciclosporin has long been used systemically to decrease the deleterious effects of inflammation. Ciclosporin is a calcineurin inhibitor that acts by primarily blocking the action of T cells, decreasing the release of pro-inflammatory cytokines, and preventing the apoptosis of goblet cells.
This article reviews the clinical trials and safety profile of an ophthalmic preparation of ciclosporin in the treatment of dry eye.
RESULTS/CONCLUSION: Clinical trials have demonstrated that ciclosporin minimizes the signs and symptoms of dry eye disease and is not associated with any significant systemic or ocular adverse reaction.
干眼症是眼科护理中最常见的病症之一，炎症是常见表现。环孢素长期以来一直用于全身治疗以减轻炎症的有害影响。环孢素是一种钙调神经磷酸酶抑制剂，主要通过阻断T细胞的作用、减少促炎细胞因子的释放以及防止杯状细胞凋亡来发挥作用。
本文综述了环孢素眼用制剂治疗干眼症的临床试验及安全性。
结果/结论：临床试验表明，环孢素可将干眼症的体征和症状降至最低，且与任何显著的全身或眼部不良反应无关。
