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催乳素在大鼠睾丸中的结合:间质细胞中的特异性受体。

Prolactin binding in rat testis: specific receptors in interstitial cells.

作者信息

Charreau E H, Attramadal A, Torjesen P A, Purvis K, Calandra R, Hansson V

出版信息

Mol Cell Endocrinol. 1977 Feb;6(4-5):303-7. doi: 10.1016/0303-7207(77)90104-6.

Abstract

Specific receptors for [125I]hPrl (human prolactin) are present in membrane preparations of rat testis. The receptors are specific for lactogenic hormones (prolactin and human growth hormone) but do not bind gonadotropins. The prolactin receptors are localized exclusively in the interstitial cell tissue, and are not present in membrane preparations from isolated seminiferous tubules. The localization of prolactin receptors interstitial tissue suggests that the effect of prolactin on LH/hCG-stimulated testosterone production is due to a direct effect of prolactin of Leydig cells.

摘要

大鼠睾丸的膜制剂中存在[125I]人催乳素(hPrl)的特异性受体。这些受体对催乳激素(催乳素和人生长激素)具有特异性,但不结合促性腺激素。催乳素受体仅定位于间质细胞组织,在分离的生精小管的膜制剂中不存在。催乳素受体在间质组织中的定位表明,催乳素对LH/hCG刺激的睾酮产生的影响是由于催乳素对睾丸间质细胞的直接作用。

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