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[一名非免疫抑制患者自疫区返回10年后被诊断为慢性肺组织胞浆菌病]

[Chronic pulmonary histoplasmosis diagnosed in a nonimmunosuppressed patient 10 years after returning from an endemic area].

作者信息

García-Marrón Manuel, García-García José María, Pajín-Collada Mercedes, Alvarez-Navascués Fernando, Martínez-Muñiz Manuel A, Sánchez-Antuña Andrés A

机构信息

Sección de Neumología, Hospital San Agustín, Avilés, Asturias, España.

出版信息

Arch Bronconeumol. 2008 Oct;44(10):567-70.

Abstract

We report the case of a Spanish nonimmunosuppressed patient who was a chronic alcoholic and who developed chronic cavitary pulmonary histoplasmosis. He had been living in Venezuela until 10 years ago. The diagnosis was established when Histoplasma capsulatum was cultured from bronchoscopy samples. The patient was treated with itraconazole and progressed favorably until cure. This case suggests that histoplasmosis can reactivate years after exposure, even when significant immunodeficiency is not present. In the absence of another immunosuppressive factor, alcoholism may have played a role in the development of the condition.

摘要

我们报告了一例西班牙患者,该患者非免疫抑制状态,是一名慢性酒精中毒者,患慢性空洞型肺组织胞浆菌病。直到10年前他一直生活在委内瑞拉。当从支气管镜检查样本中培养出荚膜组织胞浆菌时确诊。患者接受伊曲康唑治疗,病情顺利好转直至治愈。该病例表明,组织胞浆菌病可在接触数年之后复发,即使不存在明显免疫缺陷。在没有其他免疫抑制因素的情况下,酗酒可能在该病的发生中起了作用。

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