人类B细胞耐受的一条固有途径。
An innate path to human B cell tolerance.
作者信息
Bolland Silvia
机构信息
Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.
出版信息
Immunity. 2008 Nov 14;29(5):667-9. doi: 10.1016/j.immuni.2008.10.001.
Abstract
Self-reactive B cells are eliminated during development by antibody-affinity selection and receptor-editing mechanisms. Work by Isnardi et al. (2008) in this issue of Immunity suggests that removal of autoreactivity from the immature B cell pool also requires innate immunity pathways.
摘要
自身反应性B细胞在发育过程中通过抗体亲和力选择和受体编辑机制被清除。伊斯纳迪等人（2008年）在本期《免疫》杂志上发表的研究表明，从未成熟B细胞库中去除自身反应性也需要天然免疫途径。
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