Bolland Silvia
Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.
Immunity. 2008 Nov 14;29(5):667-9. doi: 10.1016/j.immuni.2008.10.001.
Self-reactive B cells are eliminated during development by antibody-affinity selection and receptor-editing mechanisms. Work by Isnardi et al. (2008) in this issue of Immunity suggests that removal of autoreactivity from the immature B cell pool also requires innate immunity pathways.
自身反应性B细胞在发育过程中通过抗体亲和力选择和受体编辑机制被清除。伊斯纳迪等人(2008年)在本期《免疫》杂志上发表的研究表明,从未成熟B细胞库中去除自身反应性也需要天然免疫途径。