The Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Fertil Steril. 2009 Dec;92(6):1920-3. doi: 10.1016/j.fertnstert.2008.09.033. Epub 2008 Nov 11.
To determine normative levels of inhibin B and examine levels in relationship to FSH, sperm count, and motility in a cohort of fertile and infertile men from the Northeast United States.
Prospective comparative study of inhibin B levels in fertile and infertile patient groups.
Tertiary academic referral center.
PATIENT(S): Fertile men were recruited among those presenting for elective vasectomy. Men being evaluated for infertility were also recruited within the same practice.
INTERVENTION(S): Serum collection.
MAIN OUTCOME MEASURE(S): FSH and inhibin B levels were measured in serum samples.
RESULT(S): A total of 55 fertile and 85 presenting for infertility evaluations were recruited. The mean serum inhibin B level was significantly higher in the fertile (138 pg/mL) than infertile group (78 pg/mL). Inhibin B levels correlated positively (R(2) = 0.27) and FSH correlated negatively (R(2) = 0.33) with total sperm concentration. General linear model multiple regression demonstrated that the FSH and inhibin B were equally predictive of sperm concentration.
CONCLUSION(S): Inhibin B levels in fertile men and infertile men in Northeast America were similar but not identical to those reported in other geographic regions. Both inhibin B and FSH are useful markers of spermatogenesis.
确定内抑制素 B 的正常水平，并研究其与 FSH、精子计数和活力在来自美国东北部的生育力正常和不育男性队列中的关系。
生育力正常和不育患者组内抑制素 B 水平的前瞻性比较研究。
三级学术转诊中心。
生育力正常的男性是从那些选择进行输精管切除术的人当中招募的。在同一诊所，也招募了正在接受不育评估的男性。
血清采集。
血清样本中 FSH 和内抑制素 B 水平的测量。
共招募了 55 名生育力正常和 85 名接受不育评估的男性。生育力正常组（138pg/ml）的血清内抑制素 B 水平明显高于不育组（78pg/ml）。内抑制素 B 水平与总精子浓度呈正相关（R²=0.27），FSH 与总精子浓度呈负相关（R²=0.33）。多元线性回归分析表明，FSH 和内抑制素 B 对精子浓度的预测作用相同。
来自美国东北部的生育力正常男性和不育男性的内抑制素 B 水平与其他地理区域报道的水平相似但不完全相同。内抑制素 B 和 FSH 都是生精作用的有用标志物。
