First Hospital of Jilin University, Changchun, 130021, China.
J Assist Reprod Genet. 2012 Jan;29(1):83-7. doi: 10.1007/s10815-011-9670-1. Epub 2011 Nov 17.
To detect the frequency and types of chromosomal anomalies with non-obstructive azoospermia and severe oligozoospermia in Northeast China, and to compare the frequencies with other regions of China and the world. To investigate the general characteristics of this population.
Eighty-one men with non-obstructive azoospermia and 54 men with severe oligozoospermia were recruited. Karyotype analyses were performed on peripheral blood lymphocytes using standard G-banding. Measurements of follicle-stimulating hormone, testosterone, prolactin, and inhibin B were obtained.
The frequency of chromosomal anomalies for patients with non-obstructive azoospermia (17.28%) was comparable with studies from Europe, Africa, Asia, and other regions of China. However, the frequency for patients with severe oligozoospermia (9.26%) was slightly higher than reported from other Asian countries. The infertile men were more likely than the fertile to smoke and consume alcohol, and to have significantly lower levels of inhibin B.
For infertile men in Northeast China, chromosome analysis is a necessary part of routine genetic testing, and the contributing effects of high smoking and alcohol consumption rates of this population should be discussed during genetic counseling.
在中国东北地区检测非梗阻性无精子症和严重少精子症患者的染色体异常频率和类型，并与中国其他地区和世界的频率进行比较。探讨该人群的一般特征。
招募了 81 名非梗阻性无精子症男性和 54 名严重少精子症男性。使用标准 G 带对外周血淋巴细胞进行核型分析。测定卵泡刺激素、睾酮、催乳素和抑制素 B。
非梗阻性无精子症患者的染色体异常频率（17.28%）与欧洲、非洲、亚洲和中国其他地区的研究相当。然而，严重少精子症患者的频率（9.26%）略高于其他亚洲国家的报道。与生育男性相比，不育男性更可能吸烟和饮酒，且抑制素 B 水平显著降低。
对于中国东北地区的不育男性，染色体分析是常规遗传检测的必要部分，在遗传咨询过程中应讨论该人群高吸烟和饮酒率的影响。
