Duborija-Kovacevic N, Jakovljevic V, Sabo A, Tomic Z
Medical school of the University of Montenegro, Department of Pharmacology, Naselje Krusevac bb, 81000 Podgorica, Montenegro.
Eur J Drug Metab Pharmacokinet. 2008 Jul-Sep;33(3):181-6. doi: 10.1007/BF03191116.
Finasteride is a potent drug which has been prescribed for the management of benign prostatic hyperplasia (BPH) for more than 20 years. Recent studies indicate that finasteride, as 5alpha-reductase inhibitor, can influence some central effects such as analgesia, neurosteroidogeneses and behavior. The purpose of this study was to investigate the analgesic effect of finasteride, to determine whether finasteride interact with morphine analgesia in tail-flick test and to examine the anti-inflammatory effect of this drug. Adult male Wistar rats (280-330 g) were used for the both of experiments. Tests were assessed on groups of 6 animals. The first control group (O) received water (1 ml/kg, p.o.), the second control group (OO) received the vehicle (olive oil, 1 ml/kg, p.o.) and the third group (F) received finasteride (0.5 mg/kg, p.o.) suspended in olive oil, every morning for 30 days. After 30 days of treatment, tail-flick test and formalin-induced foot paw edema test were performed. Finasteride increased the average latency in seconds in comparison to both controls (10.06 vs. 9.16 and 8.66 s). It was 9.83% higher depression of pain in group F in comparison to O and 16.17% in comparison to OO, but the anti-nociceptive effect of finasteride at applied dose didn't significantly differ compared to both controls (p > 0.05). Chronic pre-treatment with finasteride didn't interact with analgesic effect of morphine compared to O (p > 0.05), but compared to OO finasteride fastened, increased and prolonged the analgesic effect of morphine at all measuring intervals, achiving statistical significance in 60 min (p < 0.01). Finasteride also exhibited significant anti-inflammatory action (p < 0.05) in comparison to OO, but It was not significantly different from the control O. Finasteride didn't exert analgesic action, it increased morphine antinociception and showed chronic anti-inflammatory effect to some extent. This might be a useful contribution to highlight the pathogenesis of BPH. There is the need for further studies in order to confirm these results with more details.
非那雄胺是一种强效药物，已被用于治疗良性前列腺增生（BPH）超过20年。最近的研究表明，作为5α-还原酶抑制剂的非那雄胺可影响一些中枢效应，如镇痛、神经甾体生成和行为。本研究的目的是研究非那雄胺的镇痛作用，确定其在甩尾试验中是否与吗啡镇痛相互作用，并检测该药物的抗炎作用。成年雄性Wistar大鼠（280 - 330克）用于这两个实验。每组6只动物进行检测。第一对照组（O）给予水（1毫升/千克，口服），第二对照组（OO）给予赋形剂（橄榄油，1毫升/千克，口服），第三组（F）给予悬浮于橄榄油中的非那雄胺（0.5毫克/千克，口服），每天早晨给药，持续30天。治疗30天后，进行甩尾试验和福尔马林诱导的足爪水肿试验。与两个对照组相比，非那雄胺使平均潜伏期（以秒计）增加（10.06对9.16和8.66秒）。与O组相比，F组疼痛抑制率高9.83%，与OO组相比高16.17%，但在所用剂量下非那雄胺的抗伤害感受作用与两个对照组相比无显著差异（p > 0.05）。与O组相比，非那雄胺的慢性预处理与吗啡的镇痛作用无相互作用（p > 0.05），但与OO组相比，非那雄胺在所有测量时间间隔均增强、增加并延长了吗啡的镇痛作用，在60分钟时具有统计学意义（p < 0.01）。与OO组相比，非那雄胺还表现出显著的抗炎作用（p < 0.05），但与对照组O无显著差异。非那雄胺本身不发挥镇痛作用，它增强了吗啡的抗伤害感受作用并在一定程度上显示出慢性抗炎作用。这可能对阐明BPH的发病机制有有益贡献。需要进一步研究以更详细地证实这些结果。
