硫代莪术醇衍生物的合成及生物活性。
Synthesis and biological activities of thio-avarol derivatives.
机构信息
Istituto di Chimica Biomolecole CNR, via Campi Flegrei, 34, I-80078 Pozzuoli (Napoli), Italy.
出版信息
J Nat Prod. 2008 Nov;71(11):1850-3. doi: 10.1021/np800318m. Epub 2008 Nov 13.
PMID:19007183
Abstract
Eleven new thio-avarol derivatives (3-13) were synthesized. Their antimicrobial, brine shrimp lethality, and free-radical scavenging activities and acetylcholinesterase inhibition, together with 12 already reported semisynthetic thio-avarol derivatives (14-25), were evaluated. Structure-activity relationships among these thio derivatives were determined.
摘要
合成了 11 种新的硫代avarol 衍生物（3-13）。评估了它们的抗菌、卤虫致死、自由基清除活性和乙酰胆碱酯酶抑制活性，以及 12 种已报道的半合成硫代avarol 衍生物（14-25）。确定了这些硫代衍生物之间的构效关系。
Zotero 插件