一些2-[(苯并唑-2-基)硫代乙酰氨基]噻唑衍生物的合成及其抗菌活性和毒性
Synthesis of some 2-[(benzazole-2-yl)thioacetylamino]thiazole derivatives and their antimicrobial activity and toxicity.
作者信息
Turan-Zitouni Gülhan, Demirayak Seref, Ozdemir Ahmet, Kaplancikli Zafer Asim, Yildiz Mehmet Taha
机构信息
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey.
出版信息
Eur J Med Chem. 2004 Mar;39(3):267-72. doi: 10.1016/j.ejmech.2003.11.001.
Some 2-[(benzazole-2-yl)thioacetylamino]thiazole derivatives (III) were synthesized by reacting 4-methyl-2-(chloroacetylamino)thiazole derivatives (I) with benzazol-2-thiole (II) in acetone in the presence of K(2)CO(3). The chemical structures of the compounds were elucidated by (1)H NMR and FAB(+)-MS spectral data. The prepared compounds were tested for antimicrobial activity and toxicity.
通过使4-甲基-2-(氯乙酰氨基)噻唑衍生物(I)与苯并唑-2-硫醇(II)在碳酸钾存在下于丙酮中反应，合成了一些2-[(苯并唑-2-基)硫代乙酰氨基]噻唑衍生物(III)。通过1H NMR和FAB(+)-MS光谱数据阐明了这些化合物的化学结构。对所制备的化合物进行了抗菌活性和毒性测试。
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