Miossec Pierre
Department of Immunology and Rheumatology, Hospital Edouard Herriot, University of Lyon, 69437 Lyon, France.
Arthritis Res Ther. 2008;10 Suppl 1(Suppl 1):S2. doi: 10.1186/ar2413. Epub 2008 Oct 15.
This review focuses on the contributions made by interactions between dendritic cells (DCs) and T cells, and by local production of cytokines and chemokines to the pathogenesis of rheumatoid arthritis (RA) synovitis. DCs are efficient professional antigen-presenting cells, which are critical for the development of innate and adaptative immune responses through interactions with T cells. Cytokines from DCs play a key role in the switch inside effector T-cell pathways. Chemokines are important mediators of the immune response because they regulate leucocyte recruitment to tissue, and they play a key role in inflammatory diseases by acting on T-cell and DC migration. Furthermore, the recently discovered T-helper-17 proinflammatory cytokines, present in syno-vium samples, are associated with the migration, differentiation and maturation of inflammatory cells, and they facilitate a network of interactions between all components of the immune response. An understanding of such interactions is essential because it is the key to therapeutic application.
本综述着重探讨树突状细胞（DCs）与T细胞之间的相互作用以及细胞因子和趋化因子的局部产生对类风湿性关节炎（RA）滑膜炎发病机制的影响。DCs是高效的专职抗原呈递细胞，通过与T细胞相互作用，对先天性和适应性免疫反应的发展至关重要。DCs产生的细胞因子在效应T细胞途径的转换中起关键作用。趋化因子是免疫反应的重要介质，因为它们调节白细胞向组织的募集，并通过作用于T细胞和DC迁移在炎症性疾病中起关键作用。此外，滑膜样本中最近发现的促炎细胞因子T辅助细胞17与炎症细胞的迁移、分化和成熟有关，并促进免疫反应所有成分之间的相互作用网络。了解这种相互作用至关重要，因为它是治疗应用的关键。
