蛋白质酪氨酸硝化作用——最新进展

Protein tyrosine nitration--an update.

作者信息

Ischiropoulos Harry

机构信息

Stokes Research Institute and Departments of Pediatrics and Pharmacology, Children's Hospital of Philadelphia and The University of Pennsylvania, 417 Abramson Research Center, Philadelphia, PA 19104-4318, USA.

出版信息

Arch Biochem Biophys. 2009 Apr 15;484(2):117-21. doi: 10.1016/j.abb.2008.10.034. Epub 2008 Oct 30.

DOI:10.1016/j.abb.2008.10.034

PMID:19007743

Abstract

Tyrosine nitration is a covalent post-translational protein modification derived from the reaction of proteins with nitrating agents. Tyrosine nitration has been used as a marker of oxidant burden in human diseases. However, it remains unclear whether protein nitration is responsible for alterations in protein function that imparts an increased risk for disease development or unfavorable outcomes. Emerging data implicate tyrosine nitration as a mediator of immune responses suggesting a novel biological function for this protein modification.

摘要

酪氨酸硝化是一种共价翻译后蛋白质修饰，源自蛋白质与硝化剂的反应。酪氨酸硝化已被用作人类疾病中氧化应激负担的标志物。然而，尚不清楚蛋白质硝化是否导致蛋白质功能改变，进而增加疾病发展风险或产生不良后果。新出现的数据表明酪氨酸硝化是免疫反应的介质，提示这种蛋白质修饰具有新的生物学功能。