Mignot Tâm, Shaevitz Joshua W
Laboratoire de Chimie Bactérienne, Institut de Biologie Structurale et Microbiologie-CNRS UPR9043, 31 chemin Joseph Aiguier, 13009 Marseille, France.
Curr Opin Microbiol. 2008 Dec;11(6):580-5. doi: 10.1016/j.mib.2008.10.005. Epub 2008 Nov 18.
Spatial complexity is a hallmark of living organisms. All cells adopt specific shapes and organize their contents in such a way that makes possible fundamental tasks such as growth, metabolism, replication, and division. Although many of these tasks in bacteria have been studied extensively, only recently have we begun to understand the influence of spatial organization on cell function. Clearly, bacteria are highly organized cells where proteins do not simply diffuse in a 'cytoplasmic soup' to exert function but can also be localized to specific subcellular sites. In this review, we discuss whether such order can be achieved solely by diffusive capture mechanisms or if active intracellular transport systems are required.
空间复杂性是生物体的一个标志。所有细胞都呈现出特定的形状，并以一种使得诸如生长、新陈代谢、复制和分裂等基本任务成为可能的方式来组织其内容物。尽管细菌中的许多此类任务已得到广泛研究，但直到最近我们才开始理解空间组织对细胞功能的影响。显然，细菌是高度有组织的细胞，其中蛋白质并非简单地在“细胞质汤”中扩散以发挥功能，而是也可以定位于特定的亚细胞位点。在这篇综述中，我们讨论这种秩序是否仅能通过扩散捕获机制来实现，或者是否需要活跃的细胞内运输系统。
