Tada H, Morooka K, Arimoto K, Matsuo T
First Department of Pediatrics, Toho University School of Medicine, Tokyo, Japan.
Epilepsia. 1991 Mar-Apr;32(2):279-83. doi: 10.1111/j.1528-1157.1991.tb05256.x.
We studied the clinical efficacy of allopurinol as add-on therapy in 31 patients with intractable epilepsy. When administered for a short time, allopurinol was effective in 17 patients (55%); 8 were seizure-free, 8 had 75% decrease in seizure frequency, and 1 had greater than 50% decrease. Allopurinol was most effective in patients with localization-related epilepsy, especially in secondarily generalized tonic-clonic seizures. Allopurinol was not as effective in patients with Lennox syndrome or West syndrome, or in severe myoclonic epilepsy in infants. When allopurinol was administered greater than 1 year, its initial effectiveness continued in 8 of 14 patients who exhibited initial improvement. In 2 of the remaining 6 patients, the initial improvement disappeared during the course of treatment but control was regained by increasing the dosage of allopurinol. Mild side effects were observed in 4 patients (13%): drowsiness in 3 and abdominal pain in 1. Allopurinol may be a useful antiepileptic drug (AED), and a double-blind placebo-controlled trial should be performed.
我们研究了别嘌醇作为附加疗法对31例顽固性癫痫患者的临床疗效。短期服用时，17例患者（55%）对别嘌醇有效；8例无癫痫发作，8例癫痫发作频率降低75%，1例降低超过50%。别嘌醇对定位相关癫痫患者最为有效，尤其是对继发性全身性强直阵挛发作。别嘌醇对Lennox综合征或West综合征患者或婴儿严重肌阵挛性癫痫患者效果不佳。当别嘌醇服用超过1年时，14例最初有改善的患者中有8例仍保持其初始疗效。其余6例患者中有2例在治疗过程中最初的改善消失，但通过增加别嘌醇剂量重新获得了控制。4例患者（13%）出现轻微副作用：3例嗜睡，1例腹痛。别嘌醇可能是一种有用的抗癫痫药物（AED），应进行双盲安慰剂对照试验。
