氧化应激在难治性癫痫中的作用：来自患者和实验模型的证据。
Role of oxidative stress in refractory epilepsy: evidence in patients and experimental models.
作者信息
Cardenas-Rodriguez Noemi, Huerta-Gertrudis Bernardino, Rivera-Espinosa Liliana, Montesinos-Correa Hortencia, Bandala Cindy, Carmona-Aparicio Liliana, Coballase-Urrutia Elvia
机构信息
Laboratory of Neurochemistry, National Institute of Pediatrics, 04530, D.F., Mexico.
出版信息
Int J Mol Sci. 2013 Jan 14;14(1):1455-76. doi: 10.3390/ijms14011455.
Abstract
Oxidative stress, a state of imbalance in the production of reactive oxygen species and nitrogen, is induced by a wide variety of factors. This biochemical state is associated with systemic diseases, and diseases affecting the central nervous system. Epilepsy is a chronic neurological disorder with refractoriness to drug therapy at about 30%. Currently, experimental evidence supports the involvement of oxidative stress in seizures, in the process of their generation, and in the mechanisms associated with refractoriness to drug therapy. Hence, the aim of this review is to present information in order to facilitate the handling of this evidence and determine the therapeutic impact of the biochemical status for this pathology.
摘要
氧化应激是活性氧和氮产生失衡的一种状态，由多种因素诱发。这种生化状态与全身性疾病以及影响中枢神经系统的疾病相关。癫痫是一种慢性神经疾病，约30%的患者对药物治疗具有难治性。目前，实验证据支持氧化应激参与癫痫发作、发作产生过程以及与药物治疗难治性相关的机制。因此，本综述的目的是提供信息，以便于处理这些证据，并确定这种生化状态对该疾病的治疗影响。
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