Department of Radiology, University Hospital, Place Victor Pauchet, 80054 Amiens cedex 1, France.
Eur J Radiol. 2010 Jan;73(1):119-24. doi: 10.1016/j.ejrad.2008.09.032. Epub 2008 Nov 12.
BACKGROUND/AIMS: To measure total hepatic blood flow including portal and proper hepatic artery flows as well as the temporal evolution of the vessel's section during a cardiac cycle.
Twenty healthy subjects, with a mean age of 26 years, were explored. Magnetic resonance imaging blood flow measurements were carried out in the portal vein and the proper hepatic artery. MR studies were performed using a 1.5T imager (General Electric Medical Systems). Gradient-echo 2D Fast Cine Phase Contrast sequences were used with both cardiac and respiratory gatings. Data analysis was performed using a semi-automatic software built in our laboratory.
The total hepatic flow rate measured was 1.35+/-0.18L/min or 19.7+/-4.6mL/(minkg). The proper hepatic artery provided 19.1% of the total hepatic blood flow entering the liver. Those measurements were in agreement with earlier studies using direct measurements. Mean and maximum velocities were also assessed and a discrepancy between our values and the literature's Doppler data was found. Measurements of the portal vein area have shown a mean variation, defined as a "pulsatility" index of 18% over a cardiac cycle.
We report here proper hepatic artery blood flow rate measurements using MRI. Associated with portal flow measurements, we have shown the feasibility of total hepatic flowmetry using a non-invasive and harmless technique.
背景/目的：测量包括门静脉和肝固有动脉在内的总肝血流量以及在心动周期期间血管截面的时间演变。
对 20 名平均年龄为 26 岁的健康受试者进行了研究。在门静脉和肝固有动脉中进行了磁共振成像血流测量。MR 研究使用 1.5T 成像仪（通用电气医疗系统）进行。使用具有心脏和呼吸门控的梯度回波 2D 快速电影相位对比序列。使用我们实验室内部开发的半自动软件进行数据分析。
测量的总肝血流率为 1.35+/-0.18L/min 或 19.7+/-4.6mL/(minkg)。肝固有动脉提供了进入肝脏的总肝血流量的 19.1%。这些测量结果与使用直接测量的早期研究一致。还评估了平均和最大速度，并发现我们的值与文献中的多普勒数据之间存在差异。门静脉区域的测量值显示出平均变化，定义为心动周期内的“搏动性”指数为 18%。
我们在这里报告了使用 MRI 测量肝固有动脉血流量。结合门静脉流量测量，我们已经证明了使用非侵入性和无害技术进行总肝流量测量的可行性。
