Gandini Sara, Raimondi Sara, Gnagnarella Patrizia, Doré Jean-Francois, Maisonneuve Patrick, Testori Alessandro
Division of Epidemiology and Biostatistics, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy.
Eur J Cancer. 2009 Mar;45(4):634-41. doi: 10.1016/j.ejca.2008.10.003. Epub 2008 Nov 12.
A comprehensive bibliographic search of the literature was conducted to identify studies on Cutaneous Malignant Melanoma (CMM) and non-melanoma skin cancer (NMSC), Vitamin D receptor (VDR) polymorphisms, Vitamin D intake and 25(OH)D serum levels. Fully adjusted risk estimates were found and extracted for the two polymorphisms FokI and BsmI and Vitamin D intake. Ten studies were included in the meta-analysis, with a total of 6805 skin cancer cases. We found an association with CMM for both polymorphisms. The summary relative risks (SRR) for the studies on CMM were: 1.21 (1.03-1.42) and 1.21 (0.95-1.54) for the Ff and ff versus wild-type of FokI, respectively. The SRR for ff versus wild-type became significant with the inclusion of NMSC. The SRR for the studies on CMM were: 0.78 (0.65-0.92) and 0.75 (0.59-0.95) for the Bb and BB versus wild-type of BsmI, respectively. There is also a slight indication of a role of dietary Vitamin D in CMM development. In conclusion, this meta-analysis suggests a possible significant role of VDR FokI and BsmI polymorphism in CMM and NMSC risk. The association with Vitamin D intake is less clear and further studies could be useful to clarify the role of diet.
我们对文献进行了全面的书目检索，以确定关于皮肤恶性黑色素瘤（CMM）和非黑色素瘤皮肤癌（NMSC）、维生素D受体（VDR）多态性、维生素D摄入量和25（OH）D血清水平的研究。我们发现并提取了两种多态性FokI和BsmI以及维生素D摄入量的完全调整风险估计值。荟萃分析纳入了10项研究，共有6805例皮肤癌病例。我们发现这两种多态性均与CMM有关。CMM研究的汇总相对风险（SRR）分别为：FokI的Ff和ff与野生型相比，SRR为1.21（1.03 - 1.42）和1.21（0.95 - 1.54）。纳入NMSC后，ff与野生型相比的SRR变得显著。CMM研究的SRR分别为：BsmI的Bb和BB与野生型相比，SRR分别为0.78（0.65 - 0.92）和0.75（0.59 - 0.95）。饮食中维生素D在CMM发生中的作用也有轻微迹象。总之，这项荟萃分析表明VDR FokI和BsmI多态性在CMM和NMSC风险中可能起重要作用。与维生素D摄入量的关联不太明确，进一步的研究可能有助于阐明饮食的作用。
