Department of Plastic Surgery, Medical School, University of Ioannina, 45110 Ioannina, Greece.
Department of Nuclear Medicine, Medical School, University of Ioannina, 45110 Ioannina, Greece.
Medicina (Kaunas). 2023 Dec 7;59(12):2130. doi: 10.3390/medicina59122130.
: Previous studies revealed the anti-angiogenic, antiproliferative, and anti-inflammatory effects of Vitamin D (VitD) on cancer cells. Although this body of evidence supported the correlation of high VitD levels with reduced incidence rates for various malignancies, contradictory results were reported regarding non-melanoma skin cancer (NMSC). The aim of this overview was to summarize the available evidence from the existing pool of systematic reviews and meta-analyses, focusing on VitD serum status, dietary intake, and VitD receptor (VDR) polymorphisms in correlation to NMSC incidence. : A literature search in electronic databases was conducted from inception to January 2023. The inclusion criteria were systematic reviews and meta-analyses published in peer-reviewed journals, evaluating VitD serum levels, dietary and/or supplementary intake, or VDR gene polymorphisms, and reporting data on NMSC. A total of 10 studies were included in the data analysis models. A positive association between VitD serum levels and NMSC is highlighted. However, dietary/supplementation of VitD does not exhibit a likewise strong linkage to NMSC. Despite the contradictory findings, VDR polymorphisms may play a crucial role in the intricate NMSC pathogenesis. This umbrella review shows that high VitD levels are associated with increased NMSC incidence, potentially due to its direct correlation with increased sun exposure. Further research on VDR polymorphisms is suggested to explore their true effect size on NMSC risk.
先前的研究揭示了维生素 D（VitD）对癌细胞的抗血管生成、抗增殖和抗炎作用。尽管这一证据支持了高 VitD 水平与各种恶性肿瘤发病率降低之间的相关性，但关于非黑色素瘤皮肤癌（NMSC）的结果却相互矛盾。本综述的目的是总结现有系统评价和荟萃分析中可用的证据，重点关注 VitD 血清状态、饮食摄入以及 VitD 受体（VDR）多态性与 NMSC 发病率的相关性。从研究开始到 2023 年 1 月，我们在电子数据库中进行了文献检索。纳入标准为发表在同行评议期刊上的系统评价和荟萃分析，评估 VitD 血清水平、饮食和/或补充摄入或 VDR 基因多态性，并报告 NMSC 数据。共有 10 项研究纳入数据分析模型。VitD 血清水平与 NMSC 之间存在正相关关系。然而，饮食/补充 VitD 与 NMSC 之间没有同样强烈的联系。尽管存在相互矛盾的发现，但 VDR 多态性可能在 NMSC 发病机制中起着至关重要的作用。这项伞式综述表明，高 VitD 水平与 NMSC 发病率增加相关，这可能是由于其与增加的阳光暴露直接相关。建议进一步研究 VDR 多态性，以探索其对 NMSC 风险的真实影响大小。
