Akin Fulya, Bastemir Mehmet, Alkis Esma, Kaptanoglu Bunyamin
Department of Endocrinology and Metabolism, Pamukkale Universitesi Endokrinoloji ve Metabolizma Hastaliklari, Kinikli Kampusu 20070 Denizli, Turkey.
Indian J Med Sci. 2008 Oct;62(10):407-15.
The aim of this study was to determine sex hormone binding globulin (SHBG) concentrations in premenopausal obese women and to evaluate the relationships between sex hormones and features of the metabolic syndrome (MetS).
Retrospective cross-sectional analysis was carried out on 350 obese patients aged 25 to 69 years referred to the Department of Endocrinology, Pamukkale University in 2002-2003.
125 premenopausal euthyroid patients were eligible for this study. Subjects were divided into two groups according to the body mass index (BMI): Group I, women with BMI 2 (n = 17) and Group II,, women with BMI > or = 30 kg/m 2 (n = 108). Median SHBG concentration of Group I was 50.1 nmol/L. Group II was divided into two subgroups according to the median SHBG concentration of Group I: subjects with high SHBG levels (SHBG concentration > or = median level of the control group, i.e > or = 50.1 nmol/L) and subjects with low SHBG levels (
No significant difference was found in mean age between the low and high SHBG groups. The low SHBG group was significantly heavier, and with higher waist circumference than the high SHBG group. In the low SHBG group, fasting glucose, postprandial glucose and gamma glutamyl transferase (GGT) and free androgen index (FAI) were significantly higher. Lipid profile, blood pressure, uric acid, insulin and HOMA were found similar between two groups. Linear regression analyses revealed that body mass index and FAI were significant, being independent predictors of SHBG concentrations in premenopausal women. (r = 0.365, r square = 0.134).
It is concluded that low SHBG concentrations may indicate visceral obesity and glucose intolerance in premenopausal women.
本研究旨在测定绝经前肥胖女性的性激素结合球蛋白（SHBG）浓度，并评估性激素与代谢综合征（MetS）特征之间的关系。
对2002年至2003年转诊至帕穆卡莱大学内分泌科的350名年龄在25至69岁的肥胖患者进行回顾性横断面分析。
125名绝经前甲状腺功能正常的患者符合本研究条件。根据体重指数（BMI）将受试者分为两组：第一组，BMI<30 kg/m²的女性（n = 17）；第二组，BMI≥30 kg/m²的女性（n = 108）。第一组的SHBG浓度中位数为50.1 nmol/L。根据第一组的SHBG浓度中位数，将第二组分为两个亚组：SHBG水平高的受试者（SHBG浓度≥对照组中位数水平，即≥50.1 nmol/L）和SHBG水平低的受试者（
SHBG水平低和高的两组之间平均年龄无显著差异。SHBG水平低的组比SHBG水平高的组体重更重，腰围更大。在SHBG水平低的组中，空腹血糖、餐后血糖、γ-谷氨酰转移酶（GGT）和游离雄激素指数（FAI）显著更高。两组之间的血脂谱、血压、尿酸、胰岛素和HOMA相似。线性回归分析显示，体重指数和FAI具有显著性，是绝经前女性SHBG浓度的独立预测因素。（r = 0.365，r² = 0.134）。
得出结论，低SHBG浓度可能表明绝经前女性存在内脏肥胖和葡萄糖不耐受。
