Krupovic Mart, Bamford Dennis H
Department of Biological and Environmental Sciences, Institute of Biotechnology, Biocenter 2, PO BOX 56 (Viikinkaari 5), 00014 University of Helsinki, Finland.
Nat Rev Microbiol. 2008 Dec;6(12):941-8. doi: 10.1038/nrmicro2033.
During the past few years one of the most astonishing findings in the field of virology has been the realization that viruses that infect hosts from all three domains of life are often structurally similar. The recent burst of structural information points to a need to create a new way to organize the virosphere that, in addition to the current classification, would reflect relationships between virus families. Using the vertical beta-barrel major capsid proteins and ATPases related to known viral genome-packaging ATPases as examples, we can now re-evaluate the classification of viruses and virus-like genetic elements from a structural standpoint.
在过去几年中,病毒学领域最令人惊讶的发现之一是认识到感染生命三个域中所有宿主的病毒在结构上通常相似。最近大量的结构信息表明,需要创建一种新的方式来组织病毒圈,这种方式除了当前的分类之外,还能反映病毒家族之间的关系。以垂直β-桶状主要衣壳蛋白和与已知病毒基因组包装ATP酶相关的ATP酶为例,我们现在可以从结构的角度重新评估病毒和类病毒遗传元件的分类。