4,5-二溴噻吩-2-甲醛的区域选择性双铃木偶联反应
Regioselective double Suzuki couplings of 4,5-dibromothiophene-2-carboxaldehyde.
作者信息
Handy Scott T, Mayi Diyar
机构信息
Department of Chemistry, Middle Tennessee State University, Murfreesboro, TN 37132.
出版信息
Tetrahedron Lett. 2007 Nov 12;48(46):8108-8110. doi: 10.1016/j.tetlet.2007.09.114.
Abstract
Conditions have been identified that enable the one-pot double Suzuki coupling of 4,5-dibromothiophene-2-carboxaldehyde to proceed in good yield. The key to success in these reactions is the use of minimal amounts of water to avoid significant amounts of dehalogenation during the first coupling.
摘要
已确定了一些条件，使得4,5-二溴噻吩-2-甲醛的一锅法双铃木偶联反应能够以良好的产率进行。这些反应成功的关键在于使用极少量的水，以避免在第一次偶联过程中发生大量的脱卤反应。
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