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阴茎癌的保器官手术

Organ-preserving surgery for penile carcinoma.

作者信息

Martins Francisco E, Rodrigues Raul N, Lopes Tomé M

机构信息

Departamento de Urologia, Centro Hospitalar Lisboa Norte, Hospital de Santa Maria, Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-035 Lisboa, Portugal.

出版信息

Adv Urol. 2008;2008:634216. doi: 10.1155/2008/634216. Epub 2008 Nov 4.

Abstract

Introduction. Penile carcinoma has traditionally been treated by either surgical amputation or radical radiotherapy, both associated with devastating anatomical, functional, and psychological impact on the patient's life. Innovative surgical techniques have focused on penile preservation in well-selected patients to minimize physical disfigurement and consequently maximize quality of life. The objective of this article is to define the current status of these organ-preserving surgical options for penile carcinoma. Materials and Methods. An extensive review of the Pubmed literature was performed to find articles discussing only reconstructive surgery which have contributed significantly to change traditional, frequently mutilating treatments, to develop less disfiguring surgery, and to improve patients' quality of life over the last two decades. Results. Several articles were included in this analysis in which a major contribution to the change in therapy was thought to have occurred and was documented as beneficial. Some articles reported novel techniques of less-mutilating surgery involving different forms of glans reconstruction with the use of flaps or grafts. The issue of safe surgical margins was also addressed. Conclusion. The development of less-disfiguring techniques allowing phallus preservation has reduced the negative impact on functional and cosmetic outcomes of amputation without sacrificing oncological objectives in appropriately selected patients based on stage, grade, and location of the tumour. Until more prospective studies are available and solid evidence is documented, organ preservation should be offered with caution.

摘要

引言。阴茎癌传统上通过手术切除或根治性放疗进行治疗,这两种方法都会对患者的生活造成毁灭性的解剖学、功能和心理影响。创新的手术技术致力于在精心挑选的患者中保留阴茎,以尽量减少身体畸形,从而最大限度地提高生活质量。本文的目的是明确这些阴茎癌保留器官手术方案的现状。材料与方法。对PubMed文献进行了广泛回顾,以查找仅讨论重建手术的文章,这些文章在过去二十年中对改变传统的、常常造成毁容的治疗方法、发展创伤较小的手术以及改善患者生活质量做出了重大贡献。结果。本分析纳入了几篇文章,其中认为对治疗方法的改变有重大贡献且记录为有益。一些文章报道了创伤较小的手术新技术,包括使用皮瓣或移植物进行不同形式的龟头重建。还讨论了安全手术切缘的问题。结论。在基于肿瘤分期、分级和位置进行适当选择的患者中,创伤较小的保留阴茎技术的发展减少了截肢对功能和美容效果的负面影响,同时不牺牲肿瘤学目标。在有更多前瞻性研究且有确凿证据记录之前,应谨慎提供器官保留治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d1b/2581733/e80137d58384/AU2008-634216.001.jpg

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