三氟甲基二氮杂环丙烷：一种用于探索淀粉样蛋白形成的有效光诱导交联探针。
Trifluoromethyldiazirine: an effective photo-induced cross-linking probe for exploring amyloid formation.
作者信息
Smith David P, Anderson Jon, Plante Jeffrey, Ashcroft Alison E, Radford Sheena E, Wilson Andrew J, Parker Martin J
机构信息
Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, UK LS2 9JT.
出版信息
Chem Commun (Camb). 2008 Nov 30(44):5728-30. doi: 10.1039/b813504e. Epub 2008 Sep 30.
DOI:10.1039/b813504e
PMID:19009062
Abstract
The separative and analytical power of ion mobility spectrometry-mass spectrometry combined with photo-induced cross-linking of site-specifically incorporated trifluoromethyldiazirine provides a powerful approach towards structural characterisation of amyloid fibrils.
摘要
离子淌度光谱-质谱联用技术的分离和分析能力，结合位点特异性掺入的三氟甲基二氮杂环丙烷的光诱导交联，为淀粉样纤维的结构表征提供了一种强大的方法。
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