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铑（I）催化甲醇与烯烃通过N-甲胺的定向sp3 C-H键活化一锅法合成二烷基酮。

Rhodium(I)-catalyzed one-pot synthesis of dialkyl ketones from methanol and alkenes through directed sp3 C-H bond activation of N-methylamine.

作者信息

Jo Eun-Ae, Lee Ji-Hyun, Jun Chul-Ho

机构信息

Department of Chemistry and Centre for Bioactive Molecular Hybrid, Yonsei University, Seoul, 120-749, Korea.

出版信息

Chem Commun (Camb). 2008 Nov 30(44):5779-81. doi: 10.1039/b814166e. Epub 2008 Oct 1.

DOI:10.1039/b814166e
PMID:19009079
Abstract

The hydroacylation of methanol with alkenes was developed using a catalytic system consisting of Rh(I), 2-amino-4-picoline and benzoic acid; the reaction is speculated to occur by the initial N-methylation of 2-amino-4-picoline with methanol, and the subsequent dehydrogenation of the resulting N-methylamine, followed by double chelation-assisted hydroimination of alkene with the imine to give dialkyl ketones after hydrolysis.

摘要

利用由铑（I）、2-氨基-4-甲基吡啶和苯甲酸组成的催化体系实现了甲醇与烯烃的氢酰化反应；据推测，该反应首先是2-氨基-4-甲基吡啶与甲醇进行N-甲基化反应，然后生成的N-甲胺脱氢，接着烯烃与亚胺进行双螯合辅助氢亚胺化反应，水解后得到二烷基酮。

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