铁催化的通过自由基过程的芳基乙烯基羧酸与环烷烃的脱羧烯基化反应。
Iron-catalyzed decarboxylative alkenylation of cycloalkanes with arylvinyl carboxylic acids via a radical process.
机构信息
School of Chemistry and Chemical Engineering, State of Key Laboratory of Coordination, Nanjing University, Nanjing, 210093, China.
出版信息
Beilstein J Org Chem. 2013 Aug 21;9:1718-23. doi: 10.3762/bjoc.9.197. eCollection 2013.
Abstract
A Fe(acac)3-catalyzed decarboxylative coupling of 2-(aryl)vinyl carboxylic acids with cycloalkanes was developed by using DTBP as an oxidant through a radical process. This reaction tolerates a wide range of substrates, and products are obtained in good to excellent yields (71-95%). The reaction also shows excellent stereoselectivity, and only trans-isomers are obtained.
摘要
Fe(acac)3 催化的 2-(芳基)乙烯基羧酸与环烷烃的脱羧偶联反应是通过自由基过程，以 DTBP 作为氧化剂开发的。该反应能容忍广泛的底物，并且产物的收率良好到优秀（71-95%）。该反应还表现出优异的立体选择性，只能得到反式异构体。
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