Park Je Won, Oh Hong-Se, Jung Won Seok, Park Sung Ryeol, Han Ah Reum, Ban Yeon-Hee, Kim Eun Ji, Kang Han-Young, Yoon Yeo Joon
Department of Chemistry and Nano Science, Ewha Womans University, Seoul 120-750, Republic of Korea.
Chem Commun (Camb). 2008 Nov 30(44):5782-4. doi: 10.1039/b814603a. Epub 2008 Oct 1.
An unusual set of reduced macrolide antibiotics was discovered by combination of organic synthesis and a biosynthetic approach using the unique metabolic diversity of Streptomyces venezuelae; two unnatural 16-membered ring macrolides are also created by employing this bio-catalyst.
通过有机合成与利用委内瑞拉链霉菌独特代谢多样性的生物合成方法相结合，发现了一组不同寻常的大环内酯类抗生素；利用这种生物催化剂还合成了两种非天然的16元环大环内酯。
